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          KLH (bs-0225P)
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          說明書: 10mg  100mg  1g
          10mg/260.00元
          100mg/1800.00元
          1g/12800.00元
          大包裝/詢價
          產品編號 bs-0225P
          英文名稱 KLH Protein
          中文名稱 血藍蛋白/血藍素(進口) 蛋白質
          別    名 Keyhole limpet; keyhole limpet hemocyanin; Hemocyanin from Megathura crenulata (keyhole limpet); Hemocyanin from Limulus polyphemus hemolymph; hemocyanin; haemocyanin;   
          分 子 量 8000-9000kDa
          性    狀 Lyophilized
          多肽活性
          產品來源 提取
          分    類 天然蛋白
          偶聯蛋白
          純化方法 親和層析
          產品應用 Biological activity 
          Immunology research 
          保存條件 Store at 2-8℃.
          產品介紹 Keyhole limpet hemocyanin (KLH) is used extensively as a carrier protein in the production of antibodies for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production. KLH is the most widely employed carrier protein for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens allows a high hapten:carrier protein ratio, increasing the likelihood of generating hapten-specific antibodies. In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms.
          KLH can also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens, and are difficult to manipulate in the laboratory. A high-quality KLH preparation with clear opalescent blue color is the best indicator of KLH solubility.



          CAS:9013-72-3
          分子量:8000-9000kDa
          Type: Type VIII
          Form: lyophilized powder
          Composition: Protein, ≥85% biuret
          Copper content: 0.10-0.20% (ICP-atomic emission)
          來源:Limulus polyphemus hemolymph
          外觀:白色帶微藍色凍干粉
          介紹:血藍蛋白是在某些軟體動物、節肢動物(蜘蛛和甲殼蟲)的血淋巴中發現的一種游離的藍 色呼吸色素。血藍蛋白含兩個直接連接多肽鏈的銅離子,與含鐵的血紅蛋白類似,它易于氧結合,也易與氧解離,是已知的惟一可與氧可逆結合的銅蛋白,氧化時呈青綠色,還原時呈白色。節肢動 物中血藍蛋白的含量比軟體動物的含量要高。具有載氧功能、抗病毒活性、抗菌活性、凝血功能。
          用途:血藍蛋白是具有高度免疫原性的蛋白大分子,作為載體蛋白用于免疫原的制備,交聯于半抗原和其他抗原,增強它們的免疫原性。

          SIGMA:H1757

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